33 articles - From Friday Apr 25 2025 to Friday May 02 2025
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
| Am J Clin Nutr |
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Effect of prenatal multiple micronutrient supplementation vs iron and folic acid supplementation on size at birth and subsequent growth through 24 months of age: a systematic review and meta-analysis. Prenatal MMS improved size at birth and subsequent infant growth through six months of age, but not thereafter. Results strengthen the evidence on MMS benefits beyond birth outcomes. Prospero registration number CRD42024551864. |
| Pancreas |
FDG PET-CT vs. CT for Recurrence in Post-treatment Pancreatic Adenocarcinoma (PAC): Comparative Diagnostic Test Accuracy Systematic Review and Meta-analysis. PET-CT exhibited greater sensitivity compared to CT alone, with no significant variance in specificity between the two modalities, for recurrence evaluation in PAC. |
RCT, clinical trials, retrospective studies, etc…
| Am J Clin Nutr |
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Association of adherence to Mediterranean diet and changes over time with all-cause mortality in older adults: The Seniors-ENRICA Cohorts. Initial adherence to MD, as well as subsequent maintained or increased adherence, is associated with lower all-cause mortality in older adults, with some foods as the main drivers. |
Associations of >1-hour versus ≤1-hour meal timing variability (eating jetlag) with plasma glycemic parameters and continuous glucose monitoring measures among pregnant females: A prospective cohort study. EJL was associated with unfavourable glycemic parameters during pregnancy. Dietary interventions could promote consistent meal timing, especially in higher-risk groups with suboptimal nutritional status. |
Comparison of methods for estimating discretionary salt intake among females of reproductive age in Oromia region, Ethiopia. The WFR method, our pre-defined reference method, with repeated assessments in a subgroup of participants likely yields the most precise and accurate estimation of actual discretionary salt intake. If resource constraints preclude this method, estimating salt utilization per household member via a one-day disappearance study following preliminary WFRs to allow for potential adjustment may be an appropriate alternative. |
Inflammatory and insulinemic dietary and lifestyle patterns and incidence of endometrial cancer: The Multiethnic Cohort. In this ethnically diverse cohort, lifestyle patterns with higher insulinemic potential were associated with increased risk of EC. Lifestyle changes that include more physical activity and achieving a healthy body weight, in addition to reducing insulinemic and diets, may lower EC risk. |
Randomized dose-response trial of n-3 fatty acids in hormone receptor negative breast cancer survivors-impact on breast adipose oxylipin and DNA methylation patterns. Over 1 year, EPA+DHA dose-dependently increased breast adipose concentrations of these fatty acids and their derivative oxylipin metabolites and produced differential DNAm profiles involved in metabolism-related pathways critical to ERPR(-) breast cancer development. This distinct metabolic and epigenetic modulation of the breast microenvironment is achievable with high-dose n-3 PUFA supplementation. Clinicaltrials Gov identifier NCT02295059. |
Resistance training increases myofibrillar protein synthesis in middle-to-older aged adults consuming a typical diet with no influence of protein source: a randomized controlled trial. The 10-day provision of 1.0g·kg BM -1 ·day -1 from predominantly plant-derived or animal-derived protein does not influence daily iMyoPS rates in middle-to-older aged adults and has little impact on metabolic and renal health parameters. RET enhances rates of daily iMyoPS in middle-to-older aged adults consuming a typical protein-containing diet, with no influence of protein source. Clinical trial registry number ClinicalTrials.gov NCT05574205 |
Short-chain fatty acid kinetics and concentrations are higher after inulin supplementation in young and older adults. A randomized trial. Older adults have a lower SCFA production. Inulin intake increases SCFA production. Tracer pulse approach detects SCFA metabolism changes more sensitively than plasma or fecal concentration measurements (NCT04459156). |
Single-cell transcriptomics reveals that human milk feeding shapes neonatal immune cell interleukin signaling pathways in a non-randomized clinical trial. These findings suggest that human milk downregulates peripheral immune cell cytokine transcriptional signatures linked to allergic inflammation and infection relative to formula feeding. |
The associations between dairy intake and chronic liver disease mortality and liver cancer incidence: a prospective cohort study. High-fat dairy intake was positively associated with CLD mortality, and low-fat dairy showed inverse association. Total dairy intake was marginally positively associated with liver cancer, and milk intake was positively associated with HCC. |
| Inflamm Bowel Dis |
Biofeedback-Enhanced Cognitive-Behavioral Therapy Delivered Virtually to Youth With Inflammatory Bowel Disease: A Randomized Controlled Trial. This pilot study supports the feasibility and acceptability of a virtual, group-based HRV biofeedback-enhanced coping skills intervention for youth with IBD. Preliminary efficacy was demonstrated for reducing psychological and physical symptoms. Future research should evaluate efficacy in a larger, more diverse sample with elevated baseline psychological symptoms. |
Comparing Outcomes With Subcutaneous Infliximab (CT-P13 SC) by Baseline Immunosuppressant Use: A Post Hoc Analysis of the LIBERTY-CD and LIBERTY-UC Studies. Despite some differences in pharmacokinetics and immunogenicity between CT-P13 SC received alone or in combination with immunosuppressants in patients with CD or UC, efficacy outcomes at week 54 or week 102 were generally comparable. The overall safety profile and incidence of systemic injection reactions were also comparable between monotherapy and combination therapy. |
Fecal Microbiome Reflects Disease State and Prognosis in Inflammatory Bowel Disease in an Adult Population-Based Inception Cohort. Fecal microbiome profiling at baseline held limited potential to diagnose IBD from non-IBD compared with standard-of-care. However, microbiome shows promise for predicting future disease courses in UC. |
Lower Expression of SARS-CoV-2 Host Cell Entry Genes in the Intestinal Mucosa of IBD Patients With Quiescent or Mildly Active Disease. Overall, our study indicates that the presence of higher basal circulating levels of MBL in CD patients and the decreased intestinal mucosa expression of the SARS-CoV-2 receptor ACE2 and the host cell priming proteases TMPRSS2 and TMPRSS4 in both CD and UC patients may reduce COVID-19 risk, underscoring the potential protective role of these biomarkers in IBD populations against SARS-CoV-2 infection. |
Risk Factors for Chronic Kidney Disease in Patients With Crohn's Disease. We recommend regular kidney function monitoring and ensuring proper hydration to prevent or manage potential kidney-related complications in CD patients. Patients with resections and kidney stones are particularly vulnerable. |
Statin Use is Associated with a Less Severe Disease Course In Inflammatory Bowel Disease: A Nationwide Cohort Study 2006-2020. Statins were associated with a reduced risk of IBD-related surgery, hospitalizations, and disease flares in patients with UC, and with a reduced risk of IBD-related surgery in patients with CD. |
The Fecal Microbiome of IBD Patients Is Less Divertible by Bowel Preparation Compared to Healthy Controls: Results From a Prospective Study. Bowel preparation induced reversible short-term microbial perturbations which were less pronounced in IBD patients than in healthy comparators suggesting that a single external disruptive factor may have less impact on an already altered fecal microbiome. |
Transmural Healing Assessed by Combination of Fecal Calprotectin and Intestinal Ultrasonography Is Associated With Reduced Risk of Bowel Damage Progression in Patients With Crohn's Disease. Transmural healing, evaluated by the combination of noninvasive and well-accepted tools such as Fcal and IUS, is associated with improved long-term outcomes and could be used to monitor patients with CD in daily practice. |
| J Crohns Colitis |
A Multicenter Study of the Real-World Effectiveness and Safety of Risankizumab in Crohn's Disease. In this large multi-center cohort of patients with CD, RZB was well-tolerated and effective in achieving favorable clinical and endoscopic outcomes in both AT-exposed and naïve populations, including those with exposure to UST. |
Development and psychometric validation of a patient-reported outcome measure scale for Crohn's disease anorectal stricture. The CDAS-QoL scale is a validated PROM tool applicable to clinical decision-making and trials. It provides an effective instrument to quantify the severity of anorectal stricture in CD and assess its impact on patients' quality of life. |
Early Intestinal Ultrasound Response to Biologic and Small Molecule Therapy is Accurate to Predict Treat-To-Target Endoscopic Outcomes in Children with Ulcerative Colitis: Results from the Prospective Super Sonic-UC Study. Combining non-invasive biomarkers of BWT and the MUC on IUS, and FC, is a feasible tight control monitoring strategy in children with UC that is predictive of endoscopic outcomes. Larger, multicenter validation studies are needed to understand how an IUS and FC monitoring strategy may improve outcomes in children with UC. |
Endoscopic submucosal dissection for visible dysplasia in IBD: A nationwide multicenter cohort from the GETAID and the SFED. ESD is feasible for IBD patients with visible colorectal dysplasia and has an acceptable safety profile. These findings should be evaluated further in control trials. |
Expert Recommendations to Standardise Transcriptomic Analysis in Inflammatory Bowel Disease Clinical Trials. Persistence of existing methodologic heterogeneity may continue to limit the value of transcriptomic research in IBD. This study provides expert recommendations to address and overcome these discrepancies and foster the inclusion of this research in clinical development. |
| Liver Transpl |
Characterizing practice variations in the care of hospitalized patients with cirrhosis across the University of California Health. Through our analyses of high-dimensional EHR data, we found significant differences in care associated with admissions at transplant center and race/ethnicity. Our use of high-dimensional EHR data indicates that there is still significant room for improvement in the provision of high quality cirrhosis care. |
Safety and efficacy of continuous infusion terlipressin (BIV201): A phase 2 trial in patients with decompensated cirrhosis and refractory ascites. Despite the high rate of hyponatremia in the BIV201+SOC group (4/10 patients), the safety profile suggested that continuous BIV201 infusion was well tolerated. These findings support further development of BIV201 in confirmatory trials. |
| Pancreatology |
Risk of and factors influencing the progression from acute to recurrent acute to chronic pancreatitis. Alcohol consumption was the predominant cause of AP and RAP. The severity of the initial AP episode was the key determinant for RAP, and RAP was the most significant risk factor for the progression to CP. Therefore, smoking and alcohol cessation are important to prevent the development of recurrent AP and CP during long-term follow-up. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Inflamm Bowel Dis |
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misc publications eg case reports, tools of the trade, images of the month, etc…
| Inflamm Bowel Dis |
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| Liver Transpl |
Letters to the editors and authors’ replies
| Inflamm Bowel Dis |
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| Pancreatology |